|
KMID : 0614619950270010125
|
|
Korean Journal of Gastroenterology
1995 Volume.27 No. 1 p.125 ~ p.131
|
|
|
Three Cases of propylthiouracil-Induced Hepatitis
|
|
한형원
류형국/김인화/이일세/신영호/신현수/이경민
|
|
|
Abstract
|
|
|
although propylthiouracilis widely used for the treatment of hyperthyroidism, reports on hepatic injury by this drug are few. The clinical and histologic severity of propylthiouracil-induced hepatitis varies from mild to fulminant hepatic
failure.
Hypersensitivity is known as the principal pathophysiologic mechanism, but the precise mechanism remains obscure. Recently we e. perienced three cases of overt hepatitis induced by propylthiouracil therapy. Histologic e. amination was made in all
three
cases and revealed the features of subacute hepatic necrosis, centrilobular necrosis and chronic active hepatitis, respectively. All the patients recovered near completely after the discontinuation of propylthiouracil. Propylthiouracil rarely
develops
hepatic injury, but may induce severe hepatitis. Thus, monitoring of liver function test should be done in all patients who are receiving the drug due to thyrotoxicosis. (Korean J Gastroenterol 1995;27:125-131)
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|